Cheyney is an unincorporated community that sits astride Chester and Delaware counties in the U.S. state of Pennsylvania. It corresponds to the census-designated place known as Cheyney University, which had a population of 988 at the 2010 census. It is the home of Cheyney University of Pennsylvania. The university derive their name from George Cheyney's Farm, which became the current campus of Cheyney University in 1902. George Cheyney's Farm and the surrounding area was part of the original land grant given to William Penn in 1681.Originally, Cheyney was located at the intersection of what is now Creek and Cheyney Roads. The original "Cheyney's Shops" dated from the mid 18th century and were located on the north west and north east corners of the intersection of Creek and Cheyney Roads. The original Cheyney Post Office was located there as well as the general store, hotel, blacksmith shop and wheelsnith's shop.